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Although often referred to simply as synthetic cannabinoids, many of the substances are not structurally related to the so-called ‘classical’ cannabinoids, i.e. compounds, based on dibenzopyran. The cannabinoid receptor agonists form a diverse group, but most are lipid-soluble and non-polar, and consist of 22 to 26 carbon atoms; they would, therefore, be expected to volatilize readily when smoked.