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Drugs not to be consume before psilocybin These substances/medications should also be avoid before/during an ayahuasca ceremony: Antihypertensives (high blood pressure medicine) Appetite suppressants (diet pills) Medicine for asthma, bronchitis, or other breathing problems; antihistamines, medicines for colds, sinus problems, hay fever, or allergies (any drug containing dextromethorphan/DXM or with DM, DX, or Tuss in its name) CNS (central nervous system) depressants (xanax, ativan, etc)...