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Other reported reactions: Headache, injection site reactions, hypersensitivity reactions (angioedema, skin rashes, exfoliative dermatitis), fever, liver damage, megaloblastic anemia following chronic phenobarbital use. Animal Euthanasia However, experts in human anaesthesia have pointed out that pentobarbital, while an anaesthetic, is not a full analgesic. As such, coadministration of an appropriate analgesic may be advisable to completely eliminate risk of perceived pain, although reports...