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DMT is one of the major psychoactive compounds found in various shamanistic compounds (e.g., ayahuasca, hoasca, yagé) used in South America for centuries and has, more recently found its way into Europe and North America as a recreational drug. MDMA ( ecstasy ) MDMA ( ecstasy ) MDMA (3,4-methylenedioxymethamphetamine, also known as ecstasy) is a synthetic (man-made) drug that causes both hallucinogenic and stimulant effects.