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A microdose is typically considered to be about 1/10th to 1/20th of a full dose, and for psilocybin mushrooms, this is generally in the range of 0.1g to 0.3g (100mg to 300mg) for many people. However, the potency can vary depending on the mushroom strain and individual cultivation conditions. Therefore, 300mg of APE could be more potent than the same weight of another strain of Psilocybe cubensis.